en یک گزارش موردی از آپلازی کوتیس مادرزادی در شمال شرقی ایران تخصصي Special پژوهشي Research <span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span style="font-family:Calibri,sans-serif"><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span style="font-family:&quot;B Nazanin&quot;">آپلازی کوتیس مادرزادی</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"> (ACC) </span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span style="font-family:&quot;B Nazanin&quot;">یک اختلال مادرزادی نادر و شگفت‌انگیز است که با فقدان موضعی یا گسترده پوست، به ویژه در ناحیه سر، مشخص می‌شود. شیوع</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"> ACC </span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span style="font-family:&quot;B Nazanin&quot;">در هر 10000 نوزاد، 0.5 تا 1 نفر تخمین زده می‌شود</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%">.</span></span><span style="font-size:12.0pt"><span style="line-height:107%"><span style="font-family:&quot;B Nazanin&quot;"> این اختلال می‌تواند به اعماق مختلف پوست آسیب برساند و در برخی موارد با ناهنجاری‌های استخوانی و نقص‌های جمجمه‌ای همراه است. در حالی که پاتوفیزیولوژی دقیق این بیماری هنوز به طور کامل شناخته نشده است، عوامل ژنتیکی، عفونت‌های داخل رحمی و نارسایی عروقی به عنوان علل احتمالی آن پیشنهاد شده‌اند.</span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span style="font-family:Calibri,sans-serif"><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span style="font-family:&quot;B Nazanin&quot;">در یک مورد خاص، یک دختر بچه با ضایعه‌ای به ابعاد 3 &times; 3 سانتی‌متر در ناحیه فونتانل قدامی متولد شد و سونوگرافی مغز، تشخیص آپلازی کوتیس را تأیید کرد، بنابراین نوزاد به بخش مراقبت‌های ویژه منتقل شد</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%">.</span></span><span style="font-size:12.0pt"><span style="line-height:107%"><span style="font-family:&quot;B Nazanin&quot;"> درمان شامل تعویض منظم پانسمان و تجویز آنتی‌بیوتیک بود و خوشبختانه، سلامت نوزاد پس از چند روز بهبود یافت و مرخص شد</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%">.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span style="font-family:Calibri,sans-serif"><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span style="font-family:&quot;B Nazanin&quot;">پیش‌آگهی ضایعات کوچک معمولاً مثبت است، اما این اختلال می‌تواند منجر به عوارضی مانند عفونت و خونریزی شود. با توجه به ارتباط احتمالی بین نوع جفتی و بروز آپلازی کوتیس، تحقیقات بیشتر در این زمینه برای درک عمیق‌تر عوامل مؤثر بر این اختلال و بهبود روش‌های درمانی ضروری است.</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:107%"></span></span></span></span></span></span></span><br> &nbsp; <span style="font-size:11pt"><span style="line-height:107%"><span style="font-family:Calibri,sans-serif"><span style="font-size:10.0pt"><span style="line-height:107%"><span style="font-family:&quot;Times New Roman&quot;,serif">Aplasia Cutis</span></span></span> <span style="font-size:10.0pt"><span style="line-height:107%"><span style="font-family:&quot;Times New Roman&quot;,serif">Congenita (ACC) is a rare and astonishing congenital disorder characterized by localized or widespread absence of skin, particularly in the head region. ACC has an estimated incidence of 0.5 to 1 in every 10,000 newborns. This disorder can damage various depths of the skin and, in some cases, is associated with bone abnormalities and cranial defects. While the exact pathophysiology of this disease is not yet fully understood, genetic factors, intrauterine infections, and vascular insufficiency have been proposed as its potential causes.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:107%"><span style="font-family:Calibri,sans-serif"><span style="font-size:10.0pt"><span style="line-height:107%"><span style="font-family:&quot;Times New Roman&quot;,serif">In a specific case, a baby girl was born with a lesion measuring 3 &times; 3 centimeters in the anterior fontanel area, and brain ultrasound confirmed the diagnosis of Aplasia Cutis, so the infant was transferred to the intensive care unit. Treatment included regular dressing changes and antibiotic administration, and fortunately, the infant health improved after a few days and was discharged. </span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:107%"><span style="font-family:Calibri,sans-serif"><span style="font-size:10.0pt"><span style="line-height:107%"><span style="font-family:&quot;Times New Roman&quot;,serif">The prognosis for small lesions is usually positive, but this disorder can lead to complications such as infection and bleeding. Given the possible connection between placental type and the occurrence of Aplasia Cutis, further research in this area is essential to gain a deeper understanding of the factors influencing this disorder and to improve treatment methods.</span></span></span></span></span></span><br> &nbsp; آپلازی کوتیس مادرزادی, پاتوفیزیولوژی, پوست. Aplasia Cutis Congenita, pathophysiology, skin. 110 118 http://knjournal.ir/browse.php?a_code=A-10-119-2&slc_lang=en&sid=1 Zahra Yazdani زهرا یزدانی zahra.yazdani.64sh@gmail.com 1003194753284600754 0009-0007-4940-7046 No Shirvan School of Nursing, North Khorasan University of Medical Sciences, Bojnord, Iran. ² Nursing student, Student Research Committee, Shirvan School of Nursing, North Khorasan University of Medical Sciences, Bojnord, Iran. Hamide Kamali حمیده کمالی hamidehkamali.1381@gmail.com 1003194753284600755 1003194753284600755 No Student Research Committee, Shirvan School of Nursing, North Khorasan University of Medical Sciences, Bojnord, Iran Haniye Ghasri هانیه قصیری Haniyeghasri81@gmail.com 1003194753284600756 0009-0009-6294-4289 No Student Research Committee, Shirvan School of Nursing, North Khorasan University of Medical Sciences, Bojnord, Iran. Fatemeh Rabani فاطمه ربانی frbany645@gmail.com 1003194753284600757 1003194753284600757 No Nursing Department, Bent Al-Hoda Hospital, North Khorasan University of Medical Sciences, Bojnord, Iran. Azam Saedikia اعظم سعیدی کیا a.saedikia@nkums.ac.ir 1003194753284600758 1003194753284600758 Yes Student Research Committee, Nursing Department, Faculty of Nursing and Midwifery, Zahedan University of Medical Sciences, Zahedan, IranShirvan School of Nursing, North Khorasan University of Medical Sciences, Bojnord, Iran. ² Nursing student, Student Research Committee, Shirvan School of Nursing, North Khorasan University of Medical Sciences, Bojnord, Iran. Zobide Rafat زبیده رفعت mobinajavan@gmail.com 1003194753284600759 1003194753284600759 No Student Research Committee, Nursing Department, Faculty of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.Shirvan School of Nursing, North Khorasan University of Medical Sciences, Bojnord, Iran.