1. References 2. Charlson F, Van Ommeren M, Flaxman A, Cornett J, Whiteford H, Saxena S. New WHO Prevalence Estimates of Mental Disorders in Conflict Settings: A Systematic Review and Meta-Analysis. The Lancet. 2019;394(10194):240-8. [ DOI:10.1016/S0140-6736(19)30934-1] 3. Adebiyi MO, Mosaku SK, Irinoye OO, Oyelade OO. Socio-Demographic and Clinical Factors Associated with Relapse in Mental Illness. International Journal of Africa Nursing Sciences. 2018;8:149-53. [ DOI:10.1016/j.ijans.2018.05.007] 4. IHME. (Institute of Health Metrics and Evaluation). Global Health Data Exchange (Ghdx). [Cited 14 May 2022]. Available From: https://vizhub.healthdata.org/gbd-results/ 2022. (Accessed 2024) 5. WHO. Mental Disorders. [8 June 2022]. Available From: https://www.who.int/news-room/fact-sheets/detail/mental-disorders. (Accessed 2024) 6. Nour Bala A, Namani F, Yahyavi Dizej J, Anvari S, Mahmoudpour Azari M. Burden of Mental Disorders: A Study of the Middle East Countries for the Period 2000-2017. Journal of Medical Council of Iran. 2020;38(1):19-26. [Persian] 7. Sharifi V, Amin-Esmaeili M, Hajebi A, Motevalian A, Radgoodarzi R, Hefazi M, Rahimi-Movaghar A. Twelve-Month Prevalence and Correlates of Psychiatric Disorders in Iran: The Iranian Mental Health Survey, 2011. Archives of Iranian medicine. 2015;18(2):76-.84. [Persian] 8. Purtle J, Nelson KL, Counts NZ, Yudell M. Population-Based Approaches to Mental Health: History, Strategies, and Evidence. Annual Review of Public Health 2020;41(1):201-21. [ DOI:10.1146/annurev-publhealth-040119-094247] 9. WHO. Mental Health. [17 June 2022]. Available From: https://www.who.int/news-room/fact-sheets/detail/mental-health-strengthening-our-response. (Accessed 2024) 10. Juan-Porcar M, Guillamón-Gimeno L, Pedraz-Marcos A, Palmar-Santos AM. Family Care of People with Severe Mental Disorders: An Integrative Review. Revista Latino-Americana De Enfermagem. 2015;23(2):352-60. [ DOI:10.1590/0104-1169.0138.2562] 11. Den Boer K, De Veer AJ, Schoonmade LJ, Verhaegh KJ, Van Meijel B, Francke AL. A Systematic Review of Palliative Care Tools and Interventions for People with Severe Mental Illness. BMC Psychiatry. 2019;19:1-11. [ DOI:10.1186/s12888-019-2078-7] 12. Mötteli S, Schori D, Schmidt H, Seifritz E, Jäger M. Utilization and Effectiveness of Home Treatment for People with Acute Severe Mental Illness: A Propensity-Score Matching Analysis of 19 Months of Observation. Frontiers in Psychiatry. 2018;9 (1):495. [ DOI:10.3389/fpsyt.2018.00495] 13. Koopmans PC, Bültmann U, Roelen CA, Hoedeman R, Van Der Klink JJ, Groothoff JW. Recurrence of Sickness Absence Due to Common Mental Disorders. International Archives of Occupational and Environmental Health. 2011;84(1):193-201. [ DOI:10.1007/s00420-010-0540-4] 14. Sullivan S, Northstone K, Gadd C, Walker J, Margelyte R, Richards A, et al. Models to Predict Relapse in Psychosis: A Systematic Review. Plos One. 2017;12(9):E0183998. [ DOI:10.1371/journal.pone.0183998] 15. Caspi A, Moffitt TE. All For One and One For All: Mental Disorders in One Dimension. American Journal of Psychiatry. 2018;175(9):831-44. [ DOI:10.1176/appi.ajp.2018.17121383] 16. Durgam S, Earley W, Li R, Li D, Lu K, Laszlovszky I, et al. Long-Term Cariprazine Treatment for the Prevention of Relapse in Patients with Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Trial. Schizophrenia Research. 2016;176(2-3):264-71. [ DOI:10.1016/j.schres.2016.06.030] 17. Andreasen NC, Liu D, Ziebell S, Vora A, Ho B-C. Relapse Duration, Treatment Intensity, and Brain Tissue Loss in Schizophrenia: A Prospective Longitudinal MRI Study. American Journal of Psychiatry. 2013;170(6):609-15. [ DOI:10.1176/appi.ajp.2013.12050674] 18. Thornicroft G, Ahuja S, Barber S, Chisholm D, Collins PY, Docrat S, et al. Integrated Care for People with Long-Term Mental and Physical Health Conditions in Low-Income and Middle-Income Countries. The Lancet Psychiatry. 2019;6(2):174-86. [ DOI:10.1016/S2215-0366(18)30298-0] 19. Geller F. Business as Usual: Emergency Rooms with No Psychiatric Coverage at All. Springer International Publishing. Switzerland. 28 August 2020. pp. 13-25. [ DOI:10.1007/978-3-030-50808-1_2] 20. Maoz H, Sabbag R, Mendlovic S, Krieger I, Shefet D, Lurie I. Long-Term Efficacy of a Continuity-of-Care Treatment Model for Patients with Severe Mental Illness Who Transition from In-Patient to Out-Patient Services. The British Journal of Psychiatry. 2024;224(4):122-6. [ DOI:10.1192/bjp.2024.9] 21. Hastings SL, Cohn TJ. Challenges and Opportunities Associated with Rural Mental Health Practice. Journal of Rural Mental Health 2013;37(1):37-49. [ DOI:10.1037/rmh0000002] 22. Addo R, Agyemang SA, Tozan Y, Nonvignon J. Economic Burden of Caregiving for Persons with Severe Mental Illness in Sub-Saharan Africa: A Systematic Review. Plos One. 2018;13(8):E0199830. [ DOI:10.1371/journal.pone.0199830] 23. Broome ME. Integrative Literature Reviews for the Development of Concepts. In: Rodgers BL, Astin Knafl K, editors. Concept development in nursing: foundations, techniques and applications. Philadelphia: WB Saunders Company; 2000. pp. 231-50. 24. Gauthier G, Mucha L, Shi S, Guerin A. Economic Burden of Relapse/Recurrence in Patients with Major Depressive Disorder. Journal of Drug Assessment. 2019;8(1):97-103. [ DOI:10.1080/21556660.2019.1612410] 25. Agenagnew L, Kassaw C. The Lifetime Prevalence and Factors Associated with Relapse among Mentally Ill Patients at Jimma University Medical Center, Ethiopia: Cross Sectional Study. Journal of Psychosocial Rehabilitation and Mental Health. 2020;7(3):211-20. [ DOI:10.1007/s40737-020-00176-7] 26. Dalgard OS. Social Inequalities in Mental Health in Norway: Possible Explanatory Factors. International Journal for Equity in Health 2008;7(27):1-8. [ DOI:10.1186/1475-9276-7-27] 27. Fikreyesus M, Soboka M, Feyissa GT. Psychotic Relapse and Associated Factors among Patients Attending Health Services in Southwest Ethiopia: A Cross-Sectional Study. BMC Psychiatry. 2016;16(1):1-10. [ DOI:10.1186/s12888-016-1076-2] 28. Gbiri CA, Badru FA, Ladapo HT, Gbiri AA. Socio-Economic Correlates of Relapsed Patients Admitted in a Nigerian Mental Health Institution. International Journal of Psychiatry in Clinical Practice. 2011;15(1):19-26. [ DOI:10.3109/13651501.2010.506954] 29. Gaebel W, Riesbeck M. Are There Clinically Useful Predictors and Early Warning Signs for Pending Relapse? Schizophrenia Research. 2014;152(2-3):469-77. [ DOI:10.1016/j.schres.2013.08.003] 30. Hui CL, Lo MC, Chan EH, Chen ES, Ko RW, Lee EH, et al. Perception Towards Relapse and Its Predictors in Psychosis Patients: A Qualitative Study. Early Intervention in Psychiatry 2018;12(5):856-62. [ DOI:10.1111/eip.12378] 31. Moriarty AS, Meader N, Snell KI, Riley RD, Paton LW, Dawson S, et al. Predicting Relapse or Recurrence of Depression: Systematic Review of Prognostic Models. The British Journal of Psychiatry. 2022;221(2):448-58. [ DOI:10.1192/bjp.2021.218] 32. Saito Y, Sakurai H, Kane JM, Schooler NR, Suzuki T, Mimura M, et al. Predicting Relapse with Residual Symptoms in Schizophrenia: A Secondary Analysis of The PROACTIVE Trial. Schizophrenia Research. 2020;215:173-80. [ DOI:10.1016/j.schres.2019.10.037] 33. Alphs L, Nasrallah HA, Bossie CA, Fu D-J, Gopal S, Hough D, et al. Factors Associated with Relapse in Schizophrenia Despite Adherence to Long-Acting Injectable Antipsychotic Therapy. International Clinical Psychopharmacology. 2016;31(4):202-9. [ DOI:10.1097/YIC.0000000000000125] 34. Fond G, Bulzacka E, Boucekine M, Schürhoff F, Berna F, Godin O, et al. Machine Learning for Predicting Psychotic Relapse at 2 Years in Schizophrenia in The National FACE-SZ Cohort. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2019;92:8-18. [ DOI:10.1016/j.pnpbp.2018.12.005] 35. Lal S, Malla A, Marandola G, Thériault J, Tibbo P, Manchanda R, et al. "Worried About Relapse": Family Members' Experiences and Perspectives of Relapse in First‐Episode Psychosis. Early Intervention in Psychiatry. 2019;13(1):24-9. [ DOI:10.1111/eip.12440] 36. Gathaiya NW. Factors Associated with Relapse in Patients with Schizophrenia at Mathari Hospital, Nairobi. Doctoral dissertation, University of Nairobi, Kenya, 2011. 37. Chabungbam G, Avasthi A, Sharan P. Sociodemographic and Clinical Factors Associated with Relapse in Schizophrenia. Psychiatry and Clinical Neurosciences. 2007;61(6):587-93. [ DOI:10.1111/j.1440-1819.2007.01722.x] 38. Alvarez-Jimenez M, Priede A, Hetrick S, Bendall S, Killackey E, Parker A, et al. Risk Factors for Relapse Following Treatment for First Episode Psychosis: A Systematic Review and Meta-Analysis of Longitudinal Studies. Schizophrenia Research. 2012;139(1-3):116-28. [ DOI:10.1016/j.schres.2012.05.007] 39. Bowtell M, Eaton S, Thien K, Bardell-Williams M, Downey L, Ratheesh A, et al. Rates and Predictors of Relapse Following Discontinuation of Antipsychotic Medication After a First Episode of Psychosis. Schizophrenia Research. 2018;195(1):231-6. [ DOI:10.1016/j.schres.2017.10.030] 40. Wu NS, Schairer LC, Dellor E, Grella C. Childhood Trauma and Health Outcomes in Adults with Comorbid Substance Abuse and Mental Health Disorders. Addictive Behaviors. 2010;35(1):68-71. [ DOI:10.1016/j.addbeh.2009.09.003] 41. Davarinejad O, Mohammadi Majd T, Abbasi M, Eskandari S. Identification of Effective Factors in Recurrence of Schizophrenia Spectrum Disorder Using Poisson Regression Model. Qom University of Medical Sciences Journal. 2022;15(10):726-35. [ DOI:10.32598/qums.15.10.2522.1] 42. Chaurotia VK, Verma K, Baniya GC. A Study of Psychosocial Factor Related with Relapse in Schizophrenia. IOSR J. Dent. Med. Sci. Ver. XIV. 2016;15(4):2279-861. 43. Taylor CL, Broadbent M, Khondoker M, Stewart RJ, Howard LM. Predictors of Severe Relapse in Pregnant Women with Psychotic or Bipolar Disorders. Journal of Psychiatric Research. 2018;104:100-7. [ DOI:10.1016/j.jpsychires.2018.06.019] 44. Almond S, Knapp M, Francois C, Toumi M, Brugha T. Relapse in Schizophrenia: Costs, Clinical Outcomes and Quality of Life. The British Journal of Psychiatry. 2004;184(4):346-51. [ DOI:10.1192/bjp.184.4.346] 45. Rubio JM, Malhotra AK, Kane JM. Towards a Framework to Develop Neuroimaging Biomarkers of Relapse in Schizophrenia. Behavioural Brain Research. 2021;402:113099. [ DOI:10.1016/j.bbr.2020.113099] 46. Bubonya M, Cobb-Clark DA, Wooden M. Mental Health and Productivity at Work: Does What You Do Matter? Labour Economics. 2017;46:150-65. [ DOI:10.1016/j.labeco.2017.05.001] 47. Nenobais A, Jatimi A, Muh J. Family Burden for the Caregivers of People with Mental Disorders: A Systematic Review. 2019;14(3):26-34. [ DOI:10.20473/jn.v14i3.16971] 48. Hennemann S, Farnsteiner S, Sander L. Internet-And Mobile-Based Aftercare and Relapse Prevention in Mental Disorders: A Systematic Review and Recommendations for Future Research. Internet Interventions 2018;14 (1):1-17 [ DOI:10.1016/j.invent.2018.09.001] 49. Abu Sabra MA, Hamdan-Mansour AM. Using Relapse Prevention Interventions to Maintain Remission and Minimize Relapse Rates for Individuals with Schizophrenia: A Scoping Review. Journal of Psychosocial Nursing and Mental Health Services. 2022;60(7):47-54. [ DOI:10.3928/02793695-20220112-02] 50. Emsley R, Chiliza B, Asmal L. The Evidence for Illness Progression after Relapse in Schizophrenia. Schizophrenia Research. 2013;148(1-3):117-21. [ DOI:10.1016/j.schres.2013.05.016] 51. Lee S-U, Soh M, Ryu V, Kim C-E, Park S, Roh S, et al. Risk Factors for Relapse in Patients with First-Episode Schizophrenia: Analysis of The Health Insurance Review and Assessment Service Data From 2011 To 2015. International Journal of Mental Health Systems. 2018;12 (9):1-9. [ DOI:10.1186/s13033-018-0193-3] 52. Ayano G, Duko B. Relapse and Hospitalization in Patients with Schizophrenia and Bipolar Disorder at The St Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia: A Comparative Quantitative Cross-Sectional Study. Neuropsychiatric Disease and Treatment. 2017; 13(2017):1527-31. [ DOI:10.2147/NDT.S139075] 53. Gathaiya N, Mwaura J, Wagoro M. A Cross-Sectional Study on Factors Associated with Relapse in Patients with Schizophrenia at Mathari Hospital, Nairobi Kenya. Annals of Clinical and Laboratory Research. 2018;6(01):1-5. 54. Wu F, Huang Y, Zhou Y, Li H, Sun B, Zhong X, et al. Factors Influencing Relapse in Schizophrenia: A Longitudinal Study in China. Biomedical Research. 2017;28(9):4076-82. 55. Luciano A, Metcalfe JD, Bond GR, Xie H, Miller AL, Riley J, et al. Hospitalization Risk Before and after Employment Among Adults with Schizophrenia, Bipolar Disorder, or Major Depression. Psychiatric Services. 2016; 67(10):1131-8. [ DOI:10.1176/appi.ps.201500343] 56. Klein NS, Holtman GA, Bockting CL, Heymans MW, Burger H. Development and Validation of a Clinical Prediction Tool to Estimate the Individual Risk of Depressive Relapse or Recurrence in Individuals with Recurrent Depression. Journal of Psychiatric Research. 2018;104 (1):1-7. [ DOI:10.1016/j.jpsychires.2018.06.006] 57. Andreescu C, Ajilore O, Aizenstein HJ, Albert K, Butters MA, Landman BA, et al. Disruption of Neural Homeostasis as a Model of Relapse and Recurrence in Late-Life Depression. The American Journal of Geriatric Psychiatry. 2019;27(12):1316-30. [ DOI:10.1016/j.jagp.2019.07.016] 58. Degenhardt EK, Gatz JL, Jacob J, Tohen M. Predictors of Relapse or Recurrence in Bipolar I Disorder. Journal of Affective Disorders. 2012;136(3):733-9. [ DOI:10.1016/j.jad.2011.09.051] 59. Dijkstra-Kersten SM, Biesheuvel-Leliefeld KE, Van Der Wouden JC, Van Schaik DJ, Bosmans JE, Van Marwijk HW, et al. Supported Self-Help to Prevent Relapse or Recurrence of Depression: Who Benefits Most? Journal of Affective Disorders 2019;257:180-6. [ DOI:10.1016/j.jad.2019.07.006] 60. Gopinath S, Katon WJ, Russo JE, Ludman EJ. Clinical Factors Associated with Relapse in Primary Care Patients with Chronic or Recurrent Depression. Journal of Affective Disorders. 2007;101(1-3):57-63. [ DOI:10.1016/j.jad.2006.10.023] 61. Kazadi N, Moosa M, Jeenah F. Factors Associated with Relapse in Schizophrenia. South African Journal of Psychiatry. 2008;14(2):52-62. [ DOI:10.4102/sajpsychiatry.v14i2.158] 62. Dunn T. The Association between Medication Adherence in Mental Illness and Substance Use Disorder Relapse in Patients with Dual Diagnosis. Master's Thesis, Duquesne University, Pittsburgh, Pennsylvania. 2018: 1-24 63. Camacho-Gomez M, Castellvi P. Effectiveness of Family Intervention for Preventing Relapse in First-Episode Psychosis until 24 Months of Follow-Up: A Systematic Review with Meta-Analysis of Randomized Controlled Trials. Schizophrenia Bulletin. 2020;46(1):98-109. [ DOI:10.1093/schbul/sbz038] 64. Berwian IM, Walter H, Seifritz E, Huys QJ. Predicting Relapse after Antidepressant Withdrawal-A Systematic Review. Psychological Medicine. 2017;47(3):426-37. [ DOI:10.1017/S0033291716002580] 65. Hardeveld F. Recurrence of Major Depressive Disorder: Towards A Model of Risk. Sl: sn; 2015. 66. Wojnarowski C, Firth N, Finegan M, Delgadillo J. Predictors of Depression Relapse and Recurrence after Cognitive Behavioural Therapy: A Systematic Review and Meta-Analysis. Behavioural and Cognitive Psychotherapy. 2019;47(5):514-29. [ DOI:10.1017/S1352465819000080] 67. Etain B, Bellivier F, Olié E, Aouizerate B, Aubin V, Belzeaux R, et al. Clinical Predictors of Recurrences in Bipolar Disorders Type 1 and 2: A FACE-BD Longitudinal Study. Journal of Psychiatric Research. 2021;134:129-37. [ DOI:10.1016/j.jpsychires.2020.12.041] 68. Vigod SN, Kurdyak PA, Seitz D, Herrmann N, Fung K, Lin E, et al. Readmit: A Clinical Risk Index to Predict 30-Day Readmission after Discharge from Acute Psychiatric Units. Journal of Psychiatric Research. 2015;61(1):205-13. [ DOI:10.1016/j.jpsychires.2014.12.003] 69. Hoertel N, Blanco C, Oquendo MA, Wall MM, Olfson M, Falissard B, et al. A Comprehensive Model of Predictors of Persistence and Recurrence in Adults with Major Depression: Results from A National 3-Year Prospective Study. Journal of Psychiatric Research. 2017;95(1):19-27. [ DOI:10.1016/j.jpsychires.2017.07.022] 70. Brouwer ME, Williams AD, Kennis M, Fu Z, Klein NS, Cuijpers P, et al. Psychological Theories of Depressive Relapse and Recurrence: A Systematic Review and Meta-Analysis of Prospective Studies. Clinical Psychology Review. 2019;74(1):101773 [ DOI:10.1016/j.cpr.2019.101773] 71. San L, Bernardo M, Gómez A, Peña M. Factors Associated with Relapse in Patients with Schizophrenia. International Journal of Psychiatry in Clinical Practice. 2013;17(1):2-9. [ DOI:10.3109/13651501.2012.687452] 72. Saxena S, Jané-Llopis E, Hosman C. Prevention of Mental and Behavioural Disorders: Implications for Policy and Practice. World Psychiatry. 2006;5(1):5-14. 73. Akechi T, Mantani A, Kurata Ki, Hirota S, Shimodera S, Yamada M, et al. Predicting Relapse in Major Depression after Successful Initial Pharmacological Treatment. Journal of Affective Disorders. 2019;250(1):108-13 [ DOI:10.1016/j.jad.2019.03.004] 74. Ali S, Rhodes L, Moreea O, Mcmillan D, Gilbody S, Leach C, et al. How Durable is The Effect of Low Intensity CBT for Depression and Anxiety? Remission and Relapse in a Longitudinal Cohort Study. Behaviour Research and Therapy. 2017;94(1):1-8. [ DOI:10.1016/j.brat.2017.04.006] 75. Gulec M, Selvi Y, Boysan M, Aydin A, Besiroglu L, Agargun MY. Ongoing or Re-Emerging Subjective Insomnia Symptoms after Full/Partial Remission or Recovery of Major Depressive Disorder Mainly with The Selective Serotonin Reuptake Inhibitors and Risk of Relapse or Recurrence: A 52-Week Follow-Up Study. Journal of Affective Disorders. 2011;134(1-3):257-65. [ DOI:10.1016/j.jad.2011.05.056] 76. Brugnoli R, Rapinesi C, Kotzalidis GD, Marcellusi A, Mennini FS, De Filippis S, et al. Model of Management (Mo. Ma) for the Patient with Schizophrenia: Crisis Control, Maintenance, Relapse Prevention, and Recovery with Long-Acting Injectable Antipsychotics (Lais). Rivista Di Psichiatria. 2016;51(2):47-59. 77. Mi W-F, Chen X-M, Fan T-T, Tabarak S, Xiao J-B, Cao Y-Z, et al. Identifying Modifiable Risk Factors for Relapse in Patients with Schizophrenia in China. Frontiers in Psychiatry. 2020;11 (1):574763. [ DOI:10.3389/fpsyt.2020.574763] 78. Moges S, Belete T, Mekonen T, Menberu M. Lifetime Relapse and Its Associated Factors among People with Schizophrenia Spectrum Disorders Who are on Follow Up at Comprehensive Specialized Hospitals in Amhara Region, Ethiopia: A Cross-Sectional Study. International Journal of Mental Health Systems. 2021;15(1):1-12. [ DOI:10.1186/s13033-021-00464-0] 79. Barnett I, Torous J, Staples P, Sandoval L, Keshavan M, Onnela J-P. Relapse Prediction in Schizophrenia through Digital Phenotyping: A Pilot Study. Neuropsychopharmacology. 2018;43(8):1660-6. [ DOI:10.1038/s41386-018-0030-z] 80. De Siqueira Rotenberg L, Borges-Júnior RG, Lafer B, Salvini R, Da Silva Dias R. Exploring Machine Learning to Predict Depressive Relapses of Bipolar Disorder Patients. Journal of Affective Disorders. 2021;295(1):681-7. [ DOI:10.1016/j.jad.2021.08.127] 81. Sánchez-Guarnido AJ, Huertas P, Garcia-Solier R, Solano M, Díez B, León M, Herruzo-Cabrera J. Risk Factors for Relapse in People with Severe Mental Disorders During The COVID-19 Pandemic: A Multicenter Retrospective Study. Healthcare(Basel). 2022; 10(1):64 [ DOI:10.3390/healthcare10010064] 82. Noroozi M, Alibeigi N, Armoon B, Rezaei O, Sayadnasiri M, Nejati S, et al. Patterns of Relapse Risks and Related Factors among Patients with Schizophrenia in Razi Hospital, Iran: A Latent Class Analysis. Polish Psychological Bulletin. 2018;49(3(:) 355-359. 83. Zipursky RB, Menezes NM, Streiner DL. Risk of Symptom Recurrence with Medication Discontinuation in First-Episode Psychosis: A Systematic Review. Schizophrenia Research. 2014;152(2-3):408-14. [ DOI:10.1016/j.schres.2013.08.001] 84. Gleeson JF, Rawlings D, Jackson HJ, Mcgorry PD. Early Warning Signs of Relapse Following a First Episode of Psychosis. Schizophrenia Research. 2005;80(1):107-11. [ DOI:10.1016/j.schres.2005.07.019] 85. Eisner E, Drake R, Barrowclough C. Assessing Early Signs of Relapse in Psychosis: Review and Future Directions. Clinical Psychology Review. 2013;33(5):637-53. [ DOI:10.1016/j.cpr.2013.04.001] 86. Eisner E, Drake R, Lobban F, Bucci S, Emsley R, Barrowclough C. Comparing Early Signs and Basic Symptoms as Methods for Predicting Psychotic Relapse in Clinical Practice. Schizophrenia Research. 2018;192(1):124-30. [ DOI:10.1016/j.schres.2017.04.050] 87. Rasmussen JD, Kakuhikire B, Baguma C, Ashaba S, Cooper-Vince CE, Perkins JM, et al. Portrayals of Mental Illness, Treatment, and Relapse and Their Effects on The Stigma of Mental Illness: Population-Based, Randomized Survey Experiment in Rural Uganda. Plos Medicine. 2019;16(9):E1002908. [ DOI:10.1371/journal.pmed.1002908] 88. Salvini R, da Silva Dias R, Lafer B, Dutra I. A Multi-Relational Model for Depression Relapse in Patients with Bipolar Disorder. In MEDINFO 2015: eHealth-enabled Health. 2015; 216 (1): 741-745. 89. Bouhlel S, Jones Y, Khelifa E, Msolly M, Melki W, El-Hechmi Z. Prodromal symptoms in schizophrenic relapse: A descriptive and comparative study. L'Encéphale. 2012;38(5):397-403. [ DOI:10.1016/j.encep.2011.12.005] 90. Kennard BD, Emslie GJ, Mayes TL, Hughes JL. Relapse and Recurrence in Pediatric Depression. Child and Adolescent Psychiatric Clinics. 2006;15(4):1057-79. [ DOI:10.1016/j.chc.2006.05.003] 91. Di Capite S, Upthegrove R, Mallikarjun P. The Relapse Rate and Predictors of Relapse in Patients with First‐Episode Psychosis Following Discontinuation of Antipsychotic Medication. Early Intervention in Psychiatry. 2018;12(5):893-9. [ DOI:10.1111/eip.12385] 92. Takeuchi H, Siu C, Remington G, Fervaha G, Zipursky RB, Foussias G, et al. Does Relapse Contribute to Treatment Resistance? Antipsychotic Response in First-Vs. Second-Episode Schizophrenia. Neuropsychopharmacology. 2019;44(6):1036-42. [ DOI:10.1038/s41386-018-0278-3] 93. Montero I, Gómez-Beneyto M, Ruiz I, Puche E, Adam A. The Influence of Family Expressed Emotion on the Course of Schizophrenia in a Sample of Spanish Patients. The British Journal of Psychiatry. 1992;161(2):217-22. [ DOI:10.1192/bjp.161.2.217] 94. Ndukuba A. Socio-Demographic and Clinical Profile of Patients Admitted in to Ebonyi State University Teaching Hospital: A Three-Year Retrospective Study. Ebonyi Medical Journal. 2011;10(1):47-55. [ DOI:10.4314/ebomed.v10i1.71851] 95. Kim K-H, Lee S-M, Paik J-W, Kim N-S. The Effects of Continuous Antidepressant Treatment during the First 6 Months on Relapse or Recurrence of Depression. Journal of Affective Disorders. 2011;132(1-2):121-9. [ DOI:10.1016/j.jad.2011.02.016] 96. Pelayo-Terán JM, Galán VGG, Martínez-García O, Tabarés-Seisdedos R, Crespo-Facorro B, Ayesa-Arriola R. Rates and Predictors of Relapse in First-Episode Non-Affective Psychosis: A 3-Year Longitudinal Study in A Specialized Intervention Program (PAFIP). European Archives of Psychiatry and Clinical Neuroscience. 2017;267(4):315-23. [ DOI:10.1007/s00406-016-0740-3] 97. Larsen-Barr M, Seymour F, Read J, Gibson K. Attempting to Discontinue Antipsychotic Medication: Withdrawal Methods, Relapse and Success. Psychiatry Research. 2018;270(1):365-74. [ DOI:10.1016/j.psychres.2018.10.001] 98. Jeong H-G, Lee M-S. Long-Acting Injectable Antipsychotics in First-Episode Schizophrenia. Clinical Psychopharmacology and Neuroscience. 2013;11(1):1-6. [ DOI:10.9758/cpn.2013.11.1.1] 99. Hassan MK, Islam MI, Kamal A, Alam MJ. Factors Associated with Relapse of Schizophrenia in Bangladesh. American Journal of Psychiatry and Neuroscience 2020;8(3):64-8. [ DOI:10.11648/j.ajpn.20200803.14] 100. Schooler NR. Relapse and Rehospitalization: Comparing Oral and Depot Antipsychotics. Journal of Clinical Psychiatry. 2003;64:14-7. 101. Csernansky JG, Schuchart EK. Relapse and Rehospitalisation Rates in Patients with Schizophrenia. CNS Drugs. 2002;16(7):473-84. [ DOI:10.2165/00023210-200216070-00004] 102. Subotnik KL, Casaus LR, Ventura J, Luo JS, Hellemann GS, Gretchen-Doorly D, et al. Long-Acting Injectable Risperidone for Relapse Prevention and Control of Breakthrough Symptoms after a Recent First Episode of Schizophrenia: A Randomized Clinical Trial. JAMA Psychiatry. 2015;72(8):822-9. [ DOI:10.1001/jamapsychiatry.2015.0270] 103. Liu C-H, Zhang G-Z, Li B, Li M, Woelfer M, Walter M, et al. Role of Inflammation in Depression Relapse. Journal of Neuroinflammation. 2019;16(1):1-11. [ DOI:10.1186/s12974-019-1475-7] 104. Sfetcu R, Musat S, Haaramo P, Ciutan M, Scintee G, Vladescu C, et al. Overview of Post-Discharge Predictors for Psychiatric Re-Hospitalizations: A Systematic Review of the Literature. BMC Psychiatry 2017;17:1-15. [ DOI:10.1186/s12888-017-1386-z] 105. Fanta T, Hagos KH, Hamda EF, Haile E, Ejigu AK, Nassir Z, et al. Trends in Clinical Practice and Its Effect on Relapse Among Patients with Severe Mental Disorders in Ethiopia: A Retrospective Chart Review. Research Square 2021 [ DOI:10.21203/rs.3.rs-354506/v1] 106. Moriarty AS, Castleton J, Gilbody S, Mcmillan D, Ali S, Riley RD, et al. Predicting and Preventing Relapse of Depression in Primary Care. British Journal of General Practice; 2020, 70(691): 54-55. [ DOI:10.3399/bjgp20X707753] 107. Ahmadi A, Farahbakhsh K, Moatamedy A, Khodaei M, Safi MH. The Effectiveness of Family Psychological Training on Prevention of Recurrence of Symptoms in Patients with Schizophrenia Spectrum Disorders. Iranian Journal of Psychiatric Nursing 2020;8(3):93-103. 108. Backs-Dermott BJ, Dobson KS, Jones SL. An Evaluation of an Integrated Model of Relapse in Depression. Journal of Affective Disorders 2010;124(1-2):60-7. [ DOI:10.1016/j.jad.2009.11.015] 109. Brouwer ME, Williams AD, Forand NR, Derubeis RJ, Bockting CL. Dysfunctional Attitudes or Extreme Response Style as Predictors of Depressive Relapse and Recurrence After Mobile Cognitive Therapy for Recurrent Depression. Journal of Affective Disorders 2019;243:48-54. [ DOI:10.1016/j.jad.2018.09.002] 110. Buckman JE, Underwood A, Clarke K, Saunders R, Hollon S, Fearon P, et al. Risk Factors for Relapse and Recurrence of Depression in Adults and How They Operate: A Four-Phase Systematic Review and Meta-Synthesis. Clinical Psychology Review 2018;64:13-38. [ DOI:10.1016/j.cpr.2018.07.005] 111. Tlhowe TT, Du Plessis E, Koen MP. Strengths of Families to Limit Relapse in Mentally Ill Family Members. Health Sa Gesondheid 2017;22(1):28-35. [ DOI:10.1016/j.hsag.2016.09.003] 112. Zedan HS, Bilal L, Hyder S, Naseem MT, Akkad M, Al-Habeeb A, et al. Understanding the Burden of Mental and Physical Health Disorders on Families: Findings from The Saudi National Mental Health Survey. BMJ Open 2023;13(10):E072115. [ DOI:10.1136/bmjopen-2023-072115] 113. Ndlovu JT, Mokwena KE. Burden of Care of Family Caregivers for People Diagnosed with Serious Mental Disorders in A Rural Health District in Kwa-Zulu-Natal, South Africa. in: Healthcare: MDPI; 2023. P. 2686. [ DOI:10.20944/preprints202308.0762.v1] 114. Zareie Shabkhaneh R, Khodaei Ardakani MR, Karimlou M, Rahgozar M. Identification of Some Risk Factors of Recurrent Relapses Interval Duration in Patients with Schizoaffective Disorder. Iranian Journal of Psychiatric Nursing 2017;5(5):43-8. [ DOI:10.21859/ijpn-05056] 115. Saber S, Mardani-Hamooleh M, Seyedfatemi N. Designing and Recontextualizing the Model of Relapse in Iranian Clients with Serious Mental Illnesses. Doctoral dissertation, Iran University of Medical Sciences,Tehran, Iran, 2023. 116. Kadakia A, Catillon M, Fan Q, Williams GR, Marden JR, Anderson A, et al. The Economic Burden of Schizophrenia in the United States. The Journal of Clinical Psychiatry 2022;83(6):43278 [ DOI:10.4088/JCP.22m14458] 117. Sartorius N. The Role of Stigma as an Obstacle for Social Inclusion for People with Severe Mental Disorders. European Psychiatry 2023;66(S1):S33-S. [ DOI:10.1192/j.eurpsy.2023.128] 118. Guan Z, Poon AWC, Zwi A. Social Isolation and Loneliness in Family Caregivers of People with Severe Mental Illness: A Scoping Review. American Journal of Community Psychology 2023;72(3-4):443-63 [ DOI:10.1002/ajcp.12698] 119. Spaniel F, Bakstein E, Anyz J, Hlinka J, Sieger T, Hrdlicka J, et al. Relapse in Schizophrenia: Definitively Not a Bolt from The Blue. Neuroscience Letters 2018;669:68-74. [ DOI:10.1016/j.neulet.2016.04.044] 120. Ghoreishizadeh A, Ranjbar, F. & Pezeshki, M. Risk Factors in The Recurrence of Bipolar I Disorder and it's Relationship With Demographic Characteristics. Medical Journal of Tabriz University of Medical Sciences 2009;31:77-81. [Persian] 121. Sahoo M, Chakrabarti S, Kulhara P. Detection of Prodromal Symptoms of Relapse in Mania & Unipolar Depression by Relatives & Patients. The Indian Journal of Medical Research 2012;135(2):177-183. 122. Taylor DJ, Walters HM, Vittengl JR, Krebaum S, Jarrett RB. Which Depressive Symptoms Remain After Response to Cognitive Therapy of Depression and Predict Relapse and Recurrence? Journal of Affective Disorders 2010;123(1-3):181-7. [ DOI:10.1016/j.jad.2009.08.007]
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